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In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal.

ABSTRACT: Efinaconazole is a novel triazole antifungal drug for the topical treatment of onychomycosis, a nail infection caused mainly by dermatophytes. We assessed the potential of efinaconazole to induce resistance in dermatophytes by continuous exposure of Trichophyton rubrum strains to efinaconazole in vitro (12 passages) and in a guinea pig onychomycosis model (8 weeks). There was no evidence of efinaconazole resistance development in the tested strains under the experimental conditions used.

SUBMITTER: Iwata A

PROVIDER: S-EPMC4136074 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal.

Iwata Atsushi A Watanabe Yoko Y Kumagai Naomichi N Katafuchi-Nagashima Maria M Sugiura Keita K Pillai Radhakrishnan R Tatsumi Yoshiyuki Y

Antimicrobial agents and chemotherapy 20140527 8

Efinaconazole is a novel triazole antifungal drug for the topical treatment of onychomycosis, a nail infection caused mainly by dermatophytes. We assessed the potential of efinaconazole to induce resistance in dermatophytes by continuous exposure of Trichophyton rubrum strains to efinaconazole in vitro (12 passages) and in a guinea pig onychomycosis model (8 weeks). There was no evidence of efinaconazole resistance development in the tested strains under the experimental conditions used. ...[more]

PMID: 24867968

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