Human cytomegalovirus modulates monocyte-mediated innate immune responses during short-term experimental latency in vitro.

ABSTRACT:

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The ability of human cytomegalovirus (HCMV) to establish lifelong persistence and reactivate from latency is critical to its success as a pathogen. Here we describe a short-term in vitro model representing the events surrounding HCMV latency and reactivation in circulating peripheral blood monocytes that was developed in order to study the immunological consequence of latent virus carriage. Infection of human CD14(+) monocytes by HCMV resulted in the immediate establishment of latency, as evidenced by the absence of particular lytic gene expression, the transcription of latency-associated mRNAs, and the maintenance of viral genomes. Latent HCMV induced cellular differentiation to a macrophage lineage, causing production of selective proinflammatory cytokines and myeloid-

SUBMITTER: Noriega VM 

PROVIDER: S-EPMC4136239 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature