CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.

ABSTRACT:

Unlabelled

A unique aspect of human monocytes, compared to monocytes from many other species, is that they express the CD4 molecule. However, the role of the CD4 molecule in human monocyte development and function is not known. We determined that the activation of CD4 via interaction with major histocompatibility complex class II (MHC-II) triggers cytokine expression and the differentiation of human monocytes into functional mature macrophages. Importantly, we determined that CD4 activation induces intracellular signaling in monocytes and that inhibition of the MAPK and Src family kinase pathways blocked the ability of CD4 ligation to trigger macrophage differentiation. We observed that ligation of CD4 by MHC-II on activated endothelial cells induced CD4-mediated macrophage differe

SUBMITTER: Zhen A 

PROVIDER: S-EPMC4136363 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature