Intercontinental dispersal of HIV-1 subtype B associated with transmission among men who have sex with men in Japan.

ABSTRACT:

Unlabelled

Transmission clusters of HIV-1 subtype B uniquely associated with the epidemic among men who have sex with men (MSM) in East Asia have recently been identified. Using the Los Alamos HIV sequence database and the UK HIV drug resistance database, we explored possible links between HIV MSM epidemics in East Asia and the rest of the world by using phylogenetic and molecular clock analyses. We found that JP.MSM.B-1, a subtype B MSM variant that accounts for approximately one-third of the infections among Japanese MSM, was detected worldwide, in the United Kingdom (n=13), mainland China (n=3), the United States, Germany, Canada, and Taiwan (n=1 each). Interestingly, 10 United Kingdom samples plus two from Germany and the United States formed a distinct monophyletic subgroup wi

SUBMITTER: Takebe Y 

PROVIDER: S-EPMC4136369 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature