Relationship between impulsivity, prefrontal anticipatory activation, and striatal dopamine release during rewarded task performance.

ABSTRACT: Impulsivity, and in particular the negative urgency aspect of this trait, is associated with poor inhibitory control when experiencing negative emotion. Individual differences in aspects of impulsivity have been correlated with striatal dopamine D2/D3 receptor availability and function. This multi-modal pilot study used both positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to evaluate dopaminergic and neural activity, respectively, using modified versions of the monetary incentive delay task. Twelve healthy female subjects underwent both scans and completed the NEO Personality Inventory Revised to assess Impulsiveness (IMP). We examined the relationship between nucleus accumbens (NAcc) dopaminergic incentive/reward release, measured as a change in D2/D3 b

SUBMITTER: Weiland BJ 

PROVIDER: S-EPMC4136473 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature