When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy.

ABSTRACT: Aminoglycosides (AGs) are highly potent antibacterial agents, which are known to exert their deleterious effects on bacterial cells by interfering with the translation process, leading to aberrant protein synthesis that usually results in cell death. Nearly 45 years ago, AGs were shown to induce read-through activity in prokaryotic systems by selectively encoding tRNA molecules at premature termination codon (PTC) positions; resulting in the generation of full length functional proteins. However, only in the last 20 years this ability has been demonstrated in eukaryotic systems, highlighting their potential as therapeutic agents to treat PTC induced genetic disorders. Despite the great potential, AGs use in these manners is quite restricted due to relatively high toxicity values observed u

SUBMITTER: Shalev M 

PROVIDER: S-EPMC4136519 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature