Economic demand predicts addiction-like behavior and therapeutic efficacy of oxytocin in the rat.

ABSTRACT: Development of new treatments for drug addiction will depend on high-throughput screening in animal models. However, an addiction biomarker fit for rapid testing, and useful in both humans and animals, is not currently available. Economic models are promising candidates. They offer a structured quantitative approach to modeling behavior that is mathematically identical across species, and accruing evidence indicates economic-based descriptors of human behavior may be particularly useful biomarkers of addiction severity. However, economic demand has not yet been established as a biomarker of addiction-like behavior in animals, an essential final step in linking animal and human studies of addiction through economic models. We recently developed a mathematical approach for rapidly modeling e

SUBMITTER: Bentzley BS 

PROVIDER: S-EPMC4136574 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature