5-Aza-2'-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy.

ABSTRACT: Photodynamic therapy (PDT) of tumours is based on administration of a photosensitiser followed by irradiation of the tumour with visible light leading to production of reactive oxygen species that cause direct tumour cell death and vascular damage. PDT also initiates acute local inflammation, which facilitates the development of adaptive antitumour immunity. It has recently been reported that PDT can induce strong antitumour immunity towards tumours cells expressing P1A, tumour-associated antigen. Using four different tumour models, we show that antitumour immune response can be further improved when PDT is combined with a clinically approved epigenetic agent that induces expression of a silenced P1A antigen. Induction of P1A with 5-aza-2'-deoxycytidine, a methyltransferase inhibitor, resu

SUBMITTER: Wachowska M 

PROVIDER: S-EPMC4136636 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature