Molecular features contributing to virus-independent intracellular localization and dynamic behavior of the herpesvirus transport protein US9.

ABSTRACT: Reaching the right destination is of vital importance for molecules, proteins, organelles, and cargoes. Thus, intracellular traffic is continuously controlled and regulated by several proteins taking part in the process. Viruses exploit this machinery, and viral proteins regulating intracellular transport have been identified as they represent valuable tools to understand and possibly direct molecules targeting and delivery. Deciphering the molecular features of viral proteins contributing to (or determining) this dynamic phenotype can eventually lead to a virus-independent approach to control cellular transport and delivery. From this virus-independent perspective we looked at US9, a virion component of Herpes Simplex Virus involved in anterograde transport of the virus inside neurons of

SUBMITTER: Pedrazzi M 

PROVIDER: S-EPMC4136771 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature