Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.

ABSTRACT: Many health outcomes are influenced by a person's body mass index, as well as by the trajectory of body mass index through a lifetime. Although previous research has established that body mass index related traits are influenced by genetics, the relationship between these traits and genetics has not been well characterized in people of South Asian ancestry. To begin to characterize this relationship, we analyzed the association between common genetic variation and five phenotypes related to body mass index in a population-based sample of 5,354 Bangladeshi adults. We discovered a significant association between SNV rs347313 (intron of NOS1AP) and change in body mass index in women over two years. In a linear mixed-model, the G allele was associated with an increase of 0.25 kg/m2 in body mas

SUBMITTER: Scannell Bryan M 

PROVIDER: S-EPMC4136799 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature