Global metabolomic analysis of human saliva and plasma from healthy and diabetic subjects, with and without periodontal disease.

ABSTRACT: Recent studies suggest that periodontal disease and type 2 diabetes mellitus are bi-directionally associated. Identification of a molecular signature for periodontitis using unbiased metabolic profiling could allow identification of biomarkers to assist in the diagnosis and monitoring of both diabetes and periodontal disease. This cross-sectional study identified plasma and salivary metabolic products associated with periodontitis and/or diabetes in order to discover biomarkers that may differentiate or demonstrate an interaction of these diseases. Saliva and plasma samples were analyzed from 161 diabetic and non-diabetic human subjects with a healthy periodontium, gingivitis and periodontitis. Metabolite profiling was performed using Metabolon's platform technology. A total of 772 metabol

SUBMITTER: Barnes VM 

PROVIDER: S-EPMC4136819 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature