Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas.

ABSTRACT:

Background

Inactivation of the NF2 gene predisposes to neurofibromatosis type II and the development of schwannomas. In vitro studies have shown that loss of NF2 leads to the induction of mitogenic signaling mediated by receptor tyrosine kinases (RTKs), MAP kinase, AKT, or Hippo pathways. The goal of our study was to evaluate the expression and activity of these signaling pathways in human schwannomas in order to identify new potential therapeutic targets.

Methods

Large sets of human schwannomas, totaling 68 tumors, were analyzed using complementary proteomic approaches. RTK arrays identified the most frequently activated RTKs. The correlation between the expression and activity of signaling pathways and proliferation of tumor cells using Ki67 marker was investigated by reve

SUBMITTER: Boin A 

PROVIDER: S-EPMC4136892 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature