Survivin transcript variant 2 drives angiogenesis and malignant progression in proneural gliomas.

ABSTRACT:

Background

The influence of survivin isoforms on outcome in glioblastoma is poorly understood. We analyzed the dominant anti-apoptotic transcript variants of survivin using expression data and modeled them in vivo to determine their impact on glioma formation and progression.

Methods

Using data from low- and high-grade glioma knowledge bases, we expressed the anti-apoptotic isoforms of survivin (transcript variants 1 and 2) in vivo using the RCAS/Ntv-a model of murine glioma.

Results

In low-grade gliomas, survivin RNA expression was increased in 22 of 167 (13.2%) of cases and was associated with shortened survival (P = .005). Survivin RNA was preferentially expressed in proneural (PN) relative to mesenchymal high-grade gliomas (P < .0001). In proneural gliomas, surviv

SUBMITTER: Doucette T 

PROVIDER: S-EPMC4136894 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature