Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease.

ABSTRACT:

Introduction

Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) frequently co-occur. PSC is associated with increased risk for colorectal cancer (CRC). However, whether PSC is associated with increased risk of extraintestinal cancers or affects mortality in an IBD cohort has not been examined previously.

Methods

In a multi-institutional IBD cohort of IBD, we established a diagnosis of PSC using a novel algorithm incorporating narrative and codified data with high positive and negative predictive value. Our primary outcome was occurrence of extraintestinal and digestive tract cancers. Mortality was determined through monthly linkage to the social security master death index.

Results

In our cohort of 5506 patients with CD and 5522 patients with UC

SUBMITTER: Ananthakrishnan AN 

PROVIDER: S-EPMC4136996 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature