A new method for modeling coalescent processes with recombination.

ABSTRACT:

Background

Recombination plays an important role in the maintenance of genetic diversity in many types of organisms, especially diploid eukaryotes. Recombination can be studied and used to map diseases. However, recombination adds a great deal of complexity to the genetic information. This renders estimation of evolutionary parameters more difficult. After the coalescent process was formulated, models capable of describing recombination using graphs, such as ancestral recombination graphs (ARG) were also developed. There are two typical models based on which to simulate ARG: back-in-time model such as ms and spatial model including Wiuf&Hein's, SMC, SMC', and MaCS.

Results

In this study, a new method of modeling coalescence with recombination, Spatial Coalescent simulator (S

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4137079 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature