Discovery and validation of novel and distinct RNA regulators for ribosomal protein S15 in diverse bacterial phyla.

ABSTRACT:

Background

Autogenous cis-regulators of ribosomal protein synthesis play a critical role in maintaining the stoichiometry of ribosome components. Structured portions within an mRNA transcript typically interact with specific ribosomal proteins to prevent expression of the entire operon, thus balancing levels of ribosomal proteins across transcriptional units. Three distinct RNA structures from different bacterial phyla have demonstrated interactions with S15 to regulate gene expression; however, these RNAs are distributed across a small fraction of bacterial diversity.

Results

We used comparative genomics in combination with analysis of existing transcriptomic data to identify three novel putative RNA structures associated with the S15 coding region in microbial genomes. The

SUBMITTER: Slinger BL 

PROVIDER: S-EPMC4137082 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature