A network-based approach to dissect the cilia/centrosome complex interactome.

ABSTRACT:

Background

Cilia are microtubule-based organelles protruding from almost all mammalian cells which, when dysfunctional, result in genetic disorders called "ciliopathies". High-throughput studies have revealed that cilia are composed of thousands of proteins. However, despite many efforts, much remains to be determined regarding the biological functions of this increasingly important complex organelle.

Results

We have derived an online tool, from a systematic network-based approach to dissect the cilia/centrosome complex interactome (CCCI). The tool integrates all current available data into a model which provides an "interaction" perspective on ciliary function. We generated a network of interactions between human proteins organized into functionally relevant "communities",

SUBMITTER: Amato R 

PROVIDER: S-EPMC4137083 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature