MorFeus: a web-based program to detect remotely conserved orthologs using symmetrical best hits and orthology network scoring.

ABSTRACT:

Background

Searching the orthologs of a given protein or DNA sequence is one of the most important and most commonly used Bioinformatics methods in Biology. Programs like BLAST or the orthology search engine Inparanoid can be used to find orthologs when the similarity between two sequences is sufficiently high. They however fail when the level of conservation is low. The detection of remotely conserved proteins oftentimes involves sophisticated manual intervention that is difficult to automate.

Results

Here, we introduce morFeus, a search program to find remotely conserved orthologs. Based on relaxed sequence similarity searches, morFeus selects sequences based on the similarity of their alignments to the query, tests for orthology by iterative reciprocal BLAST searches and

SUBMITTER: Wagner I 

PROVIDER: S-EPMC4137093 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature