Antimicrobial prophylaxis for children with vesicoureteral reflux.

ABSTRACT:

Background

Children with febrile urinary tract infection commonly have vesicoureteral reflux. Because trial results have been limited and inconsistent, the use of antimicrobial prophylaxis to prevent recurrences in children with reflux remains controversial.

Methods

In this 2-year, multisite, randomized, placebo-controlled trial involving 607 children with vesicoureteral reflux that was diagnosed after a first or second febrile or symptomatic urinary tract infection, we evaluated the efficacy of trimethoprim-sulfamethoxazole prophylaxis in preventing recurrences (primary outcome). Secondary outcomes were renal scarring, treatment failure (a composite of recurrences and scarring), and antimicrobial resistance.

Results

Recurrent urinary tract infection developed in 39 o

SUBMITTER: RIVUR Trial Investigators 

PROVIDER: S-EPMC4137319 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature