Finasteride treatment alters tissue specific androgen receptor expression in prostate tissues.

ABSTRACT:

Background

Normal and pathologic growth of the prostate is dependent on the synthesis of dihydrotestosterone (DHT) from testosterone by 5α-reductase. Finasteride is a selective inhibitor of 5α-reductase 2, one isozyme of 5α-reductase found in abundance in the human prostate. The objective of this study was to investigate the effects of finasteride on androgen receptor expression and tissue morphology in human benign prostatic hyperplasia specimens.

Methods

Patients undergoing transurethral resection of the prostate and either treated or not treated with finasteride between 2004 and 2010 at the University of Wisconsin-Hospital were retrospectively identified using an institutional database. Prostate specimens from each patient were triple-stained for androgen receptor, prosta

SUBMITTER: Bauman TM 

PROVIDER: S-EPMC4137476 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature