Investigating population history using temporal genetic differentiation.

ABSTRACT: The rapid advance of sequencing technology, coupled with improvements in molecular methods for obtaining genetic data from ancient sources, holds the promise of producing a wealth of genomic data from time-separated individuals. However, the population-genetic properties of time-structured samples have not been extensively explored. Here, we consider the implications of temporal sampling for analyses of genetic differentiation and use a temporal coalescent framework to show that complex historical events such as size reductions, population replacements, and transient genetic barriers between populations leave a footprint of genetic differentiation that can be traced through history using temporal samples. Our results emphasize explicit consideration of the temporal structure when making in

SUBMITTER: Skoglund P 

PROVIDER: S-EPMC4137715 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature