Tissue-specific signals control reversible program of localization and functional polarization of macrophages.

ABSTRACT: Tissue-resident macrophages are highly heterogeneous in terms of their functions and phenotypes as a consequence of adaptation to different tissue environments. Local tissue-derived signals are thought to control functional polarization of resident macrophages; however, the identity of these signals remains largely unknown. It is also unknown whether functional heterogeneity is a result of irreversible lineage-specific differentiation or a consequence of continuous but reversible induction of diverse functional programs. Here, we identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6. We further found that GATA6 in macrophages regulates gut IgA produc

SUBMITTER: Okabe Y 

PROVIDER: S-EPMC4137874 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature