The relationship between urotensin II and its receptor and the clinicopathological parameters of breast cancer.

ABSTRACT:

Background

Urotensin II is a vasoactive polypeptide. It is known that some vasoactive polypeptides are produced and secreted by tumor cells, and act as a paracrine growth stimulant. The aim of this study was to examine the relationship between urotensin II and its receptor's messenger RNA expression in breast cancer.

Material/methods

Fifty-nine women with breast cancer were included in this study. The median age was 48 years. The relationships between urotensin II and urotensin II receptor mRNA expressions, which were derived from fresh breast cancer tissues and adjacent normal breast tissues, and clinical and pathological parameters, were assessed.

Results

We found expressions of urotensin II mRNA and its receptor in 55 of 59 breast cancer tissues and in 55 of 59 nor

SUBMITTER: Balakan O 

PROVIDER: S-EPMC4138065 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature