Gene-specific function prediction for non-synonymous mutations in monogenic diabetes genes.

ABSTRACT: The rapid progress of genomic technologies has been providing new opportunities to address the need of maturity-onset diabetes of the young (MODY) molecular diagnosis. However, whether a new mutation causes MODY can be questionable. A number of in silico methods have been developed to predict functional effects of rare human mutations. The purpose of this study is to compare the performance of different bioinformatics methods in the functional prediction of nonsynonymous mutations in each MODY gene, and provides reference matrices to assist the molecular diagnosis of MODY. Our study showed that the prediction scores by different methods of the diabetes mutations were highly correlated, but were more complimentary than replacement to each other. The available in silico methods for the predi

SUBMITTER: Li Q 

PROVIDER: S-EPMC4138110 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature