The heritability of metabolite concentrations in stored human red blood cells.

ABSTRACT:

Background

The degeneration of red blood cells (RBCs) during storage is a major issue in transfusion medicine. Family studies in the 1960s established the heritability of the RBC storage lesion based on poststorage adenosine triphosphate (ATP) concentrations. However, this critical discovery has not been further explored. In a classic twin study we confirmed the heritability of poststorage ATP concentrations and established the heritability of many other RBC metabolites.

Study design and methods

ATP concentrations and metabolomic profiles were analyzed in RBC samples from 18 twin pairs. On samples stored for 28 days, the heritability of poststorage ATP concentrations were 64 and 53% in CP2D- and AS-3-stored RBCs, respectively.

Results

Metabolomic analyses identified 8

SUBMITTER: van 't Erve TJ 

PROVIDER: S-EPMC4138246 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature