Diabetes autoantibodies do not predict progression to diabetes in adults: the Diabetes Prevention Program.

ABSTRACT:

Aims

To determine if the presence of diabetes autoantibodies predicts the development of diabetes among participants in the Diabetes Prevention Program.

Methods

A total of 3050 participants were randomized into three treatment groups: intensive lifestyle intervention, metformin and placebo. Glutamic acid decarboxylase (GAD) 65 autoantibodies and insulinoma-associated-2 autoantibodies were measured at baseline and participants were followed for 3.2 years for the development of diabetes.

Results

The overall prevalence of GAD autoantibodies was 4.0%, and it varied across racial/ethnic groups from 2.4% among Asian-Pacific Islanders to 7.0% among non-Hispanic black people. There were no significant differences in BMI or metabolic variables (glucose, insulin, HbA(1c), estim

SUBMITTER: Dabelea D 

PROVIDER: S-EPMC4138247 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature