Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium.

ABSTRACT:

Purpose

To describe associations of serum lipid levels and lipid pathway genes to the incidence of age-related macular degeneration (AMD).

Design

Meta-analysis.

Methods

setting: Three population-based cohorts. population: A total of 6950 participants from the Beaver Dam Eye Study (BDES), Blue Mountains Eye Study (BMES), and Rotterdam Study (RS). observation procedures: Participants were followed over 20 years and examined at 5-year intervals. Hazard ratios associated with lipid levels per standard deviation above the mean or associated with each additional risk allele for each lipid pathway gene were calculated using random-effects inverse-weighted meta-analysis models, adjusting for known AMD risk factors. main outcome measures: Incidence of AMD.

Results

The a

SUBMITTER: Klein R 

PROVIDER: S-EPMC4138281 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature