Tissue multifractality and Born approximation in analysis of light scattering: a novel approach for precancers detection.

ABSTRACT: Multifractal, a special class of complex self-affine processes, are under recent intensive investigations because of their fundamental nature and potential applications in diverse physical systems. Here, we report on a novel light scattering-based inverse method for extraction/quantification of multifractality in the spatial distribution of refractive index of biological tissues. The method is based on Fourier domain pre-processing via the Born approximation, followed by the Multifractal Detrended Fluctuation Analysis. The approach is experimentally validated in synthetic multifractal scattering phantoms, and tested on biopsy tissue slices. The derived multifractal properties appear sensitive in detecting cervical precancerous alterations through an increase of multifractality with patholo

SUBMITTER: Das N 

PROVIDER: S-EPMC4138517 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature