Rhodium-catalyzed ketone methylation using methanol under mild conditions: formation of α-branched products.

ABSTRACT: The rhodium-catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen-borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form α-branched products with ease. Doubly alkylated ketones can be prepared from methyl ketones and two different alcohols by using a sequential one-pot iridium- and rhodium-catalyzed process.

SUBMITTER: Chan LK 

PROVIDER: S-EPMC4138999 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature