Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies.

ABSTRACT: The understanding of gene regulation and the structure and function of the human genome increased dramatically at the end of the 20th century. Yet the technologies for manipulating the genome have been slower to develop. For instance, the field of gene therapy has been focused on correcting genetic diseases and augmenting tissue repair for more than 40 years. However, with the exception of a few very low efficiency approaches, conventional genetic engineering methods have only been able to add auxiliary genes to cells. This has been a substantial obstacle to the clinical success of gene therapies and has also led to severe unintended consequences in several cases. Therefore, technologies that facilitate the precise modification of cellular genomes have diverse and significant implications

SUBMITTER: Gersbach CA 

PROVIDER: S-EPMC4139171 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature