Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection.

ABSTRACT:

Purpose

This prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR) human papillomavirus (HPV) infection.

Methods

Among women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic regression analysis was performed, and the relative excess risk due to interaction (RERI) and synergy index (S) were calculated.

Results

Among drinkers, the risks of 1-year (odds ratio [OR] 4.09, 95% confidence interval [CI] 2.05-8.18) and 2-year persistence (OR 8.08, CI 2.36-27.6) were signif

SUBMITTER: Oh HY 

PROVIDER: S-EPMC4139267 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature