Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.

ABSTRACT:

Objective

To establish a simple two-compartment model for glomerular filtration rate (GFR) and renal plasma flow (RPF) estimations by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

Materials and methods

A total of eight New Zealand white rabbits were included in DCE-MRI. The two-compartment model was modified with the impulse residue function in this study. First, the reliability of GFR measurement of the proposed model was compared with other published models in Monte Carlo simulation at different noise levels. Then, functional parameters were estimated in six healthy rabbits to test the feasibility of the new model. Moreover, in order to investigate its validity of GFR estimation, two rabbits underwent acute ischemia surgical procedure in unilateral kidney

SUBMITTER: Chen B 

PROVIDER: S-EPMC4139329 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature