The evolution of enzyme function in the isomerases.

ABSTRACT: The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.

SUBMITTER: Martinez Cuesta S 

PROVIDER: S-EPMC4139412 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature