Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study.

ABSTRACT:

Objectives

Chromosome 9p21 single nucleotide polymorphism (SNP) is a susceptibility variant for acute myocardial infarction (AMI) in the primary prevention setting. However, it is controversial whether this SNP is also associated with recurrent myocardial infarction (ReMI) in the secondary prevention setting. The purpose of this study is to evaluate the impact of chromosome 9p21 SNP on ReMI in patients receiving secondary prevention programmes after AMI.

Design

A prospective observational study.

Setting

Osaka Acute Coronary Insufficiency Study (OACIS) in Japan.

Participants

2022 patients from the OACIS database.

Interventions

Genotyping of the 9p21 rs1333049 variant.

Primary outcome measures

ReMI event after survival discharge for 1 year.

Resul

SUBMITTER: Hara M 

PROVIDER: S-EPMC4139637 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature