Targeting intensive versus conventional glycaemic control for type 1 diabetes mellitus: a systematic review with meta-analyses and trial sequential analyses of randomised clinical trials.

ABSTRACT:

Objective

To assess the benefits and harms of targeting intensive versus conventional glycaemic control in patients with type 1 diabetes mellitus.

Design

A systematic review with meta-analyses and trial sequential analyses of randomised clinical trials.

Data sources

The Cochrane Library, MEDLINE, EMBASE, Science Citation Index Expanded and LILACS to January 2013.

Study selection

Randomised clinical trials that prespecified different targets of glycaemic control in participants at any age with type 1 diabetes mellitus were included.

Data extraction

Two authors independently assessed studies for inclusion and extracted data.

Results

18 randomised clinical trials included 2254 participants with type 1 diabetes mellitus. All trials had high risk of bi

SUBMITTER: Kahler P 

PROVIDER: S-EPMC4139659 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature