Induction of resistant mutants of Salmonella enterica serotype Typhi under ciprofloxacin selective pressure.

ABSTRACT:

Background & objectives

Infection with Salmonella enterica serovar Typhi (hereafter S. Typhi) is an important public health problem in India. There has been an increase in the number of reported clinical failures to ciprofloxacin treatment but the data on possible mechanism of failure are limited. One mechanism that has been widely reported and found associated with ciprofloxacin resistance, is the mutations in target genes in QRDR (quinolone resistance determining region). It is hypothesized that mutations in DNA gyrase or topoisomerase IV result in therapeutic failure under selective pressure of antibiotic while the patient is on treatment. We undertook in vitro sequential selection studies to expose the clinical isolates of S. Typhi to different concentration of ciprofloxacin to

SUBMITTER: Dahiya S 

PROVIDER: S-EPMC4140040 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature