Schistosome syntenin partially protects vaccinated mice against Schistosoma mansoni infection.

ABSTRACT:

Background

Schistosomiasis is a neglected tropical disease caused by several species of trematode of the genus Schistosoma. The disease affects more than 200 million people in the world and causes up to 280,000 deaths per year, besides having high morbidity due to chronic illness that damages internal organs. Current schistosomiasis control strategies are mainly based on chemotherapy, but many researchers believe that the best long-term strategy to control disease is a combination of drug treatment and immunization with an anti-schistosome vaccine. Among the most promising molecules as vaccine candidates are the proteins present in the tegument and digestive tract of the parasite.

Methodology/principal findings

In this study, we describe for the first time Schistosoma manson

SUBMITTER: Figueiredo BC 

PROVIDER: S-EPMC4140676 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature