Prenatal expression patterns of genes associated with neuropsychiatric disorders.

ABSTRACT:

Objective

Neurodevelopmental disorders presumably involve events that occur during brain development. The authors hypothesized that neuropsychiatric disorders considered to be developmental in etiology are associated with susceptibility genes that are relatively upregulated during fetal life (i.e., differentially expressed).

Method

The authors investigated the presence of prenatal expression enrichment of susceptibility genes systematically, as composite gene sets associated with six neuropsychiatric disorders in the microarray-based "BrainCloud" dorsolateral prefrontal cortex transcriptome.

Results

Using a fetal/postnatal log2-fold change threshold of 0.5, genes associated with syndromic neurodevelopmental disorders (N=31 genes, p=3.37×10-3), intellectual disability

SUBMITTER: Birnbaum R 

PROVIDER: S-EPMC4140692 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature