Dynamic modularity of host protein interaction networks in Salmonella Typhi infection.

ABSTRACT:

Background

Salmonella Typhi is a human-restricted pathogen, which causes typhoid fever and remains a global health problem in the developing countries. Although previously reported host expression datasets had identified putative biomarkers and therapeutic targets of typhoid fever, the underlying molecular mechanism of pathogenesis remains incompletely understood.

Methods

We used five gene expression datasets of human peripheral blood from patients suffering from S. Typhi or other bacteremic infections or non-infectious disease like leukemia. The expression datasets were merged into human protein interaction network (PIN) and the expression correlation between the hubs and their interacting proteins was measured by calculating Pearson Correlation Coefficient (PCC) values. Th

SUBMITTER: Dhal PK 

PROVIDER: S-EPMC4140748 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature