Everolimus-eluting stents improve vascular response in a diabetic animal model.

ABSTRACT:

Background

Preclinical evaluation of the vascular response of drug-eluting stents is limited especially in the setting of diabetes mellitus preventing the evaluation of changes in drug-eluting stent design and eluted drugs after clinical use.

Methods and results

Cultured human aortic endothelial cells were used to assess the differences between sirolimus and its analog, everolimus, in the setting of hyperglycemia on various cellular functions necessary for endothelial recovery. A diabetic rabbit model of iliac artery stenting was used to compare histological and morphometric characteristics of the vascular response to everolimus-eluting, sirolimus-eluting, and bare metal stent placement. Under hyperglycemic conditions, sirolimus impaired human aortic endothelial cell barrier

SUBMITTER: Habib A 

PROVIDER: S-EPMC4140961 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature