Fibrosis-related biomarkers and incident cardiovascular disease in older adults: the cardiovascular health study.

ABSTRACT:

Background

Fibrotic changes in the heart and arteries have been implicated in a diverse range of cardiovascular diseases (CVD), but whether circulating biomarkers that reflect fibrosis are associated with CVD is unknown.

Methods and results

We determined the associations of 2 biomarkers of fibrosis, transforming growth factor- β (TGF-β), and procollagen type III N-terminal propeptide (PIIINP), with incident heart failure, myocardial infarction, and stroke among community-living older adults in the Cardiovascular Health Study. We measured circulating TGF-β (n=1371) and PIIINP (n=2568) from plasma samples collected in 1996 and ascertained events through 2010. Given TGF-β's pleiotropic effects on inflammation and fibrogenesis, we investigated potential effect modification by C-

SUBMITTER: Agarwal I 

PROVIDER: S-EPMC4140969 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature