Polymorphisms in estrogen receptors predict the risk of male infertility: a meta-analysis.

ABSTRACT:

Background

Estrogen receptors play an important role in mediating estrogen action on target tissues, and the estrogen is relevant to male infertility. Single nucleotide polymorphisms (SNPs) in estrogen receptors may be associated with the risk of male infertility. A variety of case control studies have been published evaluating this association. However, the accumulated studies have shown inconsistent conclusions.

Methods

To further determine the potential association between the four common SNPs (rs2234693, rs9340799, rs1256049 and rs4986938) in estrogen receptors gene and male infertility, this meta-analysis was performed according to the 10 published case control studies. The odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the strength of the associ

SUBMITTER: Li TF 

PROVIDER: S-EPMC4141121 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature