Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals.

ABSTRACT:

Context

Risk markers including coronary artery calcium, carotid intima-media thickness, ankle-brachial index, brachial flow-mediated dilation, high-sensitivity C-reactive protein (CRP), and family history of coronary heart disease (CHD) have been reported to improve on the Framingham Risk Score (FRS) for prediction of CHD, but there are no direct comparisons of these markers for risk prediction in a single cohort.

Objective

We compared improvement in prediction of incident CHD/cardiovascular disease (CVD) of these 6 risk markers within intermediate-risk participants (FRS >5%-<20%) in the Multi-Ethnic Study of Atherosclerosis (MESA).

Design, setting, and participants

Of 6814 MESA participants from 6 US field centers, 1330 were intermediate risk, without diabetes mellit

SUBMITTER: Yeboah J 

PROVIDER: S-EPMC4141475 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature