Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.

ABSTRACT:

Objective

Interindividual variation in pathways affecting cellular cholesterol metabolism can influence levels of plasma cholesterol, a well-established risk factor for cardiovascular disease. Inherent variation among immortalized lymphoblastoid cell lines from different donors can be leveraged to discover novel genes that modulate cellular cholesterol metabolism. The objective of this study was to identify novel genes that regulate cholesterol metabolism by testing for evidence of correlated gene expression with cellular levels of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) mRNA, a marker for cellular cholesterol homeostasis, in a large panel of lymphoblastoid cell lines.

Approach and results

Expression array profiling was performed on 480 lymphoblastoid cell lines est

SUBMITTER: Medina MW 

PROVIDER: S-EPMC4141484 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature