Hollow iron-silica nanoshells for enhanced high intensity focused ultrasound.

ABSTRACT:

Background

High intensity-focused ultrasound (HIFU) is an alterative ablative technique currently being investigated for local treatment of breast cancer and fibroadenomas. Current HIFU therapies require concurrent magnetic resonance imaging monitoring. Biodegradable 500 nm perfluoropentane-filled iron-silica nanoshells have been synthesized as a sensitizing agent for HIFU therapies, which aid both mechanical and thermal ablation of tissues. In low duty cycle high-intensity applications, rapid tissue damage occurs from mechanical rather than thermal effects, which can be monitored closely by ultrasound obviating the need for concurrent magnetic resonance imaging.

Materials and methods

Iron-silica nanoshells were synthesized by a sol-gel method on polystyrene templates and ca

SUBMITTER: Liberman A 

PROVIDER: S-EPMC4141695 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature