Association between AVPR1A, DRD2, and ASPM and endophenotypes of communication disorders.

ABSTRACT:

Objectives

Speech sound disorder (SSD) is one of the most common communication disorders, with a prevalence rate of 16% at 3 years of age, and an estimated 3.8% of children still presenting speech difficulties at 6 years of age. Several studies have identified promising associations between communication disorders and genes in brain and neuronal pathways; however, there have been few studies focusing on SSD and its associated endophenotypes. On the basis of the hypothesis that neuronal genes may influence endophenotypes common to communication disorders, we focused on three genes related to brain and central nervous system functioning: the dopamine D2 receptor (DRD2) gene, the arginine-vasopressin receptor 1a (AVPR1A) gene, and the microcephaly-associated protein gene (ASPM).

Me

SUBMITTER: Stein CM 

PROVIDER: S-EPMC4141900 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature