Comparative genomics of 274 Vibrio cholerae genomes reveals mobile functions structuring three niche dimensions.

ABSTRACT:

Background

Vibrio cholerae is a globally dispersed pathogen that has evolved with humans for centuries, but also includes non-pathogenic environmental strains. Here, we identify the genomic variability underlying this remarkable persistence across the three major niche dimensions space, time, and habitat.

Results

Taking an innovative approach of genome-wide association applicable to microbial genomes (GWAS-M), we classify 274 complete V. cholerae genomes by niche, including 39 newly sequenced for this study with the Ion Torrent DNA-sequencing platform. Niche metadata were collected for each strain and analyzed together with comprehensive annotations of genetic and genomic attributes, including point mutations (single-nucleotide polymorphisms, SNPs), protein families, functio

SUBMITTER: Dutilh BE 

PROVIDER: S-EPMC4141962 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature