Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells.

ABSTRACT:

Background

The human dicer1 gene has been predicted to produce several mRNA variants that encode truncated Dicer1 proteins of varying lengths. One of these Dicer1 variants, Dicer1e, was recently found to be differentially expressed in breast cancer cells. Because the expression and function of the Dicer1e protein variant has not been well characterized and the underlying molecular mechanisms for the development of oral squamous cell carcinomas (OSCCs) are poorly understood, the present study sought to characterize the biological role of Dicer1e and determine its relationship, if any, to OSCC pathogenesis.

Methods

Western blot analyses were used to examine Dicer1e expression levels in a panel of oral cancer cells/tissues and during epithelial-mesenchymal transition (EMT), fol

SUBMITTER: Cantini LP 

PROVIDER: S-EPMC4141963 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature