Outcome after surgical or conservative management of cerebral cavernous malformations.

ABSTRACT:

Objective

There have been few comparative studies of microsurgical excision vs conservative management of cerebral cavernous malformations (CCM) and none of them has reliably demonstrated a statistically and clinically significant difference.

Methods

We conducted a prospective, population-based study to identify and independently validate definite CCM diagnoses first made in 1999-2003 in Scottish adult residents. We used multiple sources of prospective follow-up to assess adults' dependence and to identify and independently validate outcome events. We used univariate and multivariable survival analyses to test the influence of CCM excision on outcome, adjusted for prognostic factors and baseline imbalances.

Results

Of 134 adults, 25 underwent CCM excision; these adult

SUBMITTER: Moultrie F 

PROVIDER: S-EPMC4141991 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature