Untreated brain arteriovenous malformation: patient-level meta-analysis of hemorrhage predictors.

ABSTRACT:

Objective

To identify risk factors for intracranial hemorrhage in the natural history course of brain arteriovenous malformations (AVMs) using individual patient data meta-analysis of 4 existing cohorts.

Methods

We harmonized data from Kaiser Permanente of Northern California (n = 856), University of California San Francisco (n = 787), Columbia University (n = 672), and the Scottish Intracranial Vascular Malformation Study (n = 210). We censored patients at first treatment, death, last visit, or 10-year follow-up, and performed stratified Cox regression analysis of time-to-hemorrhage after evaluating hemorrhagic presentation, sex, age at diagnosis, deep venous drainage, and AVM size as predictors. Multiple imputation was performed to assess impact of missing data.

Results

SUBMITTER: Kim H 

PROVIDER: S-EPMC4141996 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature